Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice
Identifieur interne : 000405 ( Main/Exploration ); précédent : 000404; suivant : 000406Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice
Auteurs : Mustafa Ababneh [Jordanie] ; Mu En Alrwashdeh [Jordanie] ; Mohammad Khalifeh [Jordanie]Source :
- Veterinary World [ 0972-8988 ] ; 2019.
Abstract
Mice were immunized initially by intramuscular injection and boosted 3 weeks later by intranasal application. Expression of the S1 protein in the lungs and kidneys was detected using conventional polymerase chain reaction (PCR) and immunohistochemistry (IHC) targeting specific regions within the S1 subunit at weeks 3, 4, 5, and 6 after the first vaccination. Antigen-specific humoral and cellular immune responses were evaluated in serum and in cell culture following
S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime. The vaccine elicited a specific S1-immunoglobulin G antibody response, which was detected in the sera of the vaccinated mice at weeks 4 and 6 from the onset of the first immunization. There was a significant increase in the amount of Th1-related cytokines (interferon-γ and interleukin [IL] 12), and a significant decrease in the Th2-related cytokine IL-4 in splenocyte cell culture of the vaccinated group compared with the control groups.
The results of this study suggest that this recombinant adenovirus vaccine encoding the S1 subunit of MERS-CoV elicits potentially protective antigen-specific humoral and cellular immune responses in mice. This study demonstrates a promising vaccine for the control and/or prevention of MERS-CoV infection in humans.
Url:
DOI: 10.14202/vetworld.2019.1554-1562
PubMed: 31849416
PubMed Central: 6868266
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recombinant adenoviral vaccine encoding the spike 1 subunit of the <italic>Middle East Respiratory Syndrome Coronavirus</italic> elicits strong humoral and cellular immune responses in mice</title><author><name sortKey="Ababneh, Mustafa" sort="Ababneh, Mustafa" uniqKey="Ababneh M" first="Mustafa" last="Ababneh">Mustafa Ababneh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author><author><name sortKey="Alrwashdeh, Mu En" sort="Alrwashdeh, Mu En" uniqKey="Alrwashdeh M" first="Mu En" last="Alrwashdeh">Mu En Alrwashdeh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author><author><name sortKey="Khalifeh, Mohammad" sort="Khalifeh, Mohammad" uniqKey="Khalifeh M" first="Mohammad" last="Khalifeh">Mohammad Khalifeh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. 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Box 3030, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author><author><name sortKey="Alrwashdeh, Mu En" sort="Alrwashdeh, Mu En" uniqKey="Alrwashdeh M" first="Mu En" last="Alrwashdeh">Mu En Alrwashdeh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author><author><name sortKey="Khalifeh, Mohammad" sort="Khalifeh, Mohammad" uniqKey="Khalifeh M" first="Mohammad" last="Khalifeh">Mohammad Khalifeh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110</wicri:regionArea><wicri:noRegion>Irbid 22110</wicri:noRegion></affiliation></author></analytic><series><title level="j">Veterinary World</title><idno type="ISSN">0972-8988</idno><idno type="eISSN">2231-0916</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background and Aim:</title><p><italic>Middle East respiratory syndrome coronavirus</italic> (MERS-CoV) has rapidly spread throughout the Middle East since its discovery in 2012. The virus poses a significant global public health threat with potentially devastating effects. In this study, a recombinant adenoviral-based vaccine encoding the spike 1 (S1) subunit of the MERS-CoV genome was constructed, and its humoral, and cellular immune responses were evaluated in mice.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Mice were immunized initially by intramuscular injection and boosted 3 weeks later by intranasal application. Expression of the S1 protein in the lungs and kidneys was detected using conventional polymerase chain reaction (PCR) and immunohistochemistry (IHC) targeting specific regions within the S1 subunit at weeks 3, 4, 5, and 6 after the first vaccination. Antigen-specific humoral and cellular immune responses were evaluated in serum and in cell culture following <italic>in vitro</italic> stimulation with a specific 9-mer epitope within the S1 protein (CYSSLILDY).</p></sec><sec id="st3"><title>Results:</title><p>S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime. The vaccine elicited a specific S1-immunoglobulin G antibody response, which was detected in the sera of the vaccinated mice at weeks 4 and 6 from the onset of the first immunization. There was a significant increase in the amount of Th1-related cytokines (interferon-γ and interleukin [IL] 12), and a significant decrease in the Th2-related cytokine IL-4 in splenocyte cell culture of the vaccinated group compared with the control groups.</p></sec><sec id="st4"><title>Conclusion:</title><p>The results of this study suggest that this recombinant adenovirus vaccine encoding the S1 subunit of MERS-CoV elicits potentially protective antigen-specific humoral and cellular immune responses in mice. This study demonstrates a promising vaccine for the control and/or prevention of MERS-CoV infection in humans.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A Al-Tawfiq</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S Raj</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A Fouchier</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banik, G R" uniqKey="Banik G">G.R Banik</name></author><author><name sortKey="Khandaker, G" uniqKey="Khandaker G">G Khandaker</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H Rashid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M Bestebroer</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S Raj</name></author><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M Zaki</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E Gorbalenya</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J Snijder</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jamil, B" uniqKey="Jamil B">B Jamil</name></author><author><name sortKey="Habib, K" uniqKey="Habib K">K Habib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B Reusken</name></author><author><name sortKey="Ababneh, M" uniqKey="Ababneh M">M Ababneh</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S Raj</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Eljarah, A" uniqKey="Eljarah A">A Eljarah</name></author><author><name sortKey="Abutarbush, S" uniqKey="Abutarbush S">S Abutarbush</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.J Godeke</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M Bestebroer</name></author><author><name sortKey="Zutt, I" uniqKey="Zutt I">I Zutt</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A Muller</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J Bosch</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J Rottier</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author><author><name sortKey="Koopmans, M P" uniqKey="Koopmans M">M.P Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G Hemida</name></author><author><name sortKey="Perera, R A" uniqKey="Perera R">R.A Perera</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author><author><name sortKey="Alhammadi, M A" uniqKey="Alhammadi M">M.A Alhammadi</name></author><author><name sortKey="Siu, L Y" uniqKey="Siu L">L.Y Siu</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L Poon</name></author><author><name sortKey="Saif, L" uniqKey="Saif L">L Saif</name></author><author><name sortKey="Alnaeem, A" uniqKey="Alnaeem A">A Alnaeem</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author><author><name sortKey="Al Dhahiry, S H" uniqKey="Al Dhahiry S">S.H Al Dhahiry</name></author><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B Reusken</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S Raj</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R Myers</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.J Godeke</name></author><author><name sortKey="Jonges, M" uniqKey="Jonges M">M Jonges</name></author><author><name sortKey="Farag, E" uniqKey="Farag E">E Farag</name></author><author><name sortKey="Diab, A" uniqKey="Diab A">A Diab</name></author><author><name sortKey="Ghobashy, H" uniqKey="Ghobashy H">H Ghobashy</name></author><author><name sortKey="Alhajri, F" uniqKey="Alhajri F">F Alhajri</name></author><author><name sortKey="Al Thani, M" uniqKey="Al Thani M">M Al-Thani</name></author><author><name sortKey="Al Marri, S A" uniqKey="Al Marri S">S.A Al-Marri</name></author><author><name sortKey="Al Romaihi, H E" uniqKey="Al Romaihi H">H.E Al Romaihi</name></author><author><name sortKey="Al Khal, A" uniqKey="Al Khal A">A Al Khal</name></author><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Al Hajri, M M" uniqKey="Al Hajri M">M.M Al Hajri</name></author><author><name sortKey="Koopmans, M P" uniqKey="Koopmans M">M.P Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A Muller</name></author><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M Corman</name></author><author><name sortKey="Reusken, C B" uniqKey="Reusken C">C.B Reusken</name></author><author><name sortKey="Ritz, D" uniqKey="Ritz D">D Ritz</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G.J Godeke</name></author><author><name sortKey="Lattwein, E" uniqKey="Lattwein E">E Lattwein</name></author><author><name sortKey="Kallies, S" uniqKey="Kallies S">S Kallies</name></author><author><name sortKey="Siemens, A" uniqKey="Siemens A">A Siemens</name></author><author><name sortKey="Van Beek, J" uniqKey="Van Beek J">J van Beek</name></author><author><name sortKey="Drexler, J F" uniqKey="Drexler J">J.F Drexler</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J Bosch</name></author><author><name sortKey="Wernery, U" uniqKey="Wernery U">U Wernery</name></author><author><name sortKey="Koopmans, M P" uniqKey="Koopmans M">M.P Koopmans</name></author><author><name sortKey="Wernery, R" uniqKey="Wernery R">R Wernery</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E.I Azhar</name></author><author><name sortKey="Hashem, A M" uniqKey="Hashem A">A.M Hashem</name></author><author><name sortKey="El Kafrawy, S A" uniqKey="El Kafrawy S">S.A El-Kafrawy</name></author><author><name sortKey="Sohrab, S S" uniqKey="Sohrab S">S.S Sohrab</name></author><author><name sortKey="Aburizaiza, A S" uniqKey="Aburizaiza A">A.S Aburizaiza</name></author><author><name sortKey="Farraj, S A" uniqKey="Farraj S">S.A Farraj</name></author><author><name sortKey="Hassan, A M" uniqKey="Hassan A">A.M Hassan</name></author><author><name sortKey="Al Saeed, M S" uniqKey="Al Saeed M">M.S Al-Saeed</name></author><author><name sortKey="Jamjoom, G A" uniqKey="Jamjoom G">G.A Jamjoom</name></author><author><name sortKey="Madani, T A" uniqKey="Madani T">T.A Madani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="See, R H" uniqKey="See R">R.H See</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M Petric</name></author><author><name sortKey="Lawrence, D J" uniqKey="Lawrence D">D.J Lawrence</name></author><author><name sortKey="Mok, C P" uniqKey="Mok C">C.P Mok</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author><author><name sortKey="Zitzow, L A" uniqKey="Zitzow L">L.A Zitzow</name></author><author><name sortKey="Karunakaran, K P" uniqKey="Karunakaran K">K.P Karunakaran</name></author><author><name sortKey="Voss, T G" uniqKey="Voss T">T.G Voss</name></author><author><name sortKey="Brunham, R C" uniqKey="Brunham R">R.C Brunham</name></author><author><name sortKey="Gauldie, J" uniqKey="Gauldie J">J Gauldie</name></author><author><name sortKey="Finlay, B B" uniqKey="Finlay B">B.B Finlay</name></author><author><name sortKey="Roper, R L" uniqKey="Roper R">R.L Roper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Zou, X" uniqKey="Zou X">X Zou</name></author><author><name sortKey="Hung, T" uniqKey="Hung T">T Hung</name></author><author><name sortKey="Lu, Z" uniqKey="Lu Z">Z Lu</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, E" uniqKey="Kim E">E Kim</name></author><author><name sortKey="Okada, K" uniqKey="Okada K">K Okada</name></author><author><name sortKey="Kenniston, T" uniqKey="Kenniston T">T Kenniston</name></author><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S Raj</name></author><author><name sortKey="Al Hajri, M M" uniqKey="Al Hajri M">M.M Al Hajri</name></author><author><name sortKey="Farag, E A" uniqKey="Farag E">E.A Farag</name></author><author><name sortKey="Al Hajri, F" uniqKey="Al Hajri F">F Al Hajri</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author><author><name sortKey="Gambotto, A" uniqKey="Gambotto A">A Gambotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Provacia, L B" uniqKey="Provacia L">L.B Provacia</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Kupke, A" uniqKey="Kupke A">A Kupke</name></author><author><name sortKey="Song, F" uniqKey="Song F">F Song</name></author><author><name sortKey="Jany, S" uniqKey="Jany S">S Jany</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Shams Eldin, H" uniqKey="Shams Eldin H">H Shams-Eldin</name></author><author><name sortKey="Schmidt, J" uniqKey="Schmidt J">J Schmidt</name></author><author><name sortKey="Becker, C" uniqKey="Becker C">C Becker</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, S Y" uniqKey="Jung S">S.Y Jung</name></author><author><name sortKey="Kang, K W" uniqKey="Kang K">K.W Kang</name></author><author><name sortKey="Lee, Ey" uniqKey="Lee E">EY Lee</name></author><author><name sortKey="Seo, D W" uniqKey="Seo D">D.W Seo</name></author><author><name sortKey="Kim, H L" uniqKey="Kim H">H.L Kim</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Kwon, T" uniqKey="Kwon T">T Kwon</name></author><author><name sortKey="Park, H L" uniqKey="Park H">H.L Park</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Lee, S M" uniqKey="Lee S">S.M Lee</name></author><author><name sortKey="Nam, J H" uniqKey="Nam J">J.H Nam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langenmayer, M C" uniqKey="Langenmayer M">M.C Langenmayer</name></author><author><name sortKey="Lulf Averhoff, A T" uniqKey="Lulf Averhoff A">A.T Lulf-Averhoff</name></author><author><name sortKey="Adam Neumair, S" uniqKey="Adam Neumair S">S Adam-Neumair</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozharovskaia, T A" uniqKey="Ozharovskaia T">T.A Ozharovskaia</name></author><author><name sortKey="Zubkova, O V" uniqKey="Zubkova O">O.V Zubkova</name></author><author><name sortKey="Dolzhikova, I V" uniqKey="Dolzhikova I">I.V Dolzhikova</name></author><author><name sortKey="Gromova, A S" uniqKey="Gromova A">A.S Gromova</name></author><author><name sortKey="Grousova, D M" uniqKey="Grousova D">D.M Grousova</name></author><author><name sortKey="Tukhvatulin, A I" uniqKey="Tukhvatulin A">A.I Tukhvatulin</name></author><author><name sortKey="Popova, O" uniqKey="Popova O">O Popova</name></author><author><name sortKey="Shcheblyakov, D V" uniqKey="Shcheblyakov D">D.V Shcheblyakov</name></author><author><name sortKey="Scherbinin, D N" uniqKey="Scherbinin D">D.N Scherbinin</name></author><author><name sortKey="Dzharullaeva, A S" uniqKey="Dzharullaeva A">A.S Dzharullaeva</name></author><author><name sortKey="Erokhova, A S" uniqKey="Erokhova A">A.S Erokhova</name></author><author><name sortKey="Shmarov, M M" uniqKey="Shmarov M">M.M Shmarov</name></author><author><name sortKey="Loginova, S Y" uniqKey="Loginova S">S.Y Loginova</name></author><author><name sortKey="Borisevich, S V" uniqKey="Borisevich S">S.V Borisevich</name></author><author><name sortKey="Naroditsky, B S" uniqKey="Naroditsky B">B.S Naroditsky</name></author><author><name sortKey="Logunov, D Y" uniqKey="Logunov D">D.Y Logunov</name></author><author><name sortKey="Gintsburg, A L" uniqKey="Gintsburg A">A.L Gintsburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alharbi, N K" uniqKey="Alharbi N">N.K Alharbi</name></author><author><name sortKey="Padron Regalado, E" uniqKey="Padron Regalado E">E Padron-Regalado</name></author><author><name sortKey="Thompson, C P" uniqKey="Thompson C">C.P Thompson</name></author><author><name sortKey="Kupke, A" uniqKey="Kupke A">A Kupke</name></author><author><name sortKey="Wells, D" uniqKey="Wells D">D Wells</name></author><author><name sortKey="Sloan, M A" uniqKey="Sloan M">M.A Sloan</name></author><author><name sortKey="Grehan, K" uniqKey="Grehan K">K Grehan</name></author><author><name sortKey="Temperton, N" uniqKey="Temperton N">N Temperton</name></author><author><name sortKey="Lambe, T" uniqKey="Lambe T">T Lambe</name></author><author><name sortKey="Warimwe, G" uniqKey="Warimwe G">G Warimwe</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Hill, A V S" uniqKey="Hill A">A.V.S Hill</name></author><author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J Munster</name></author><author><name sortKey="Wells, D" uniqKey="Wells D">D Wells</name></author><author><name sortKey="Lambe, T" uniqKey="Lambe T">T Lambe</name></author><author><name sortKey="Wright, D" uniqKey="Wright D">D Wright</name></author><author><name sortKey="Fischer, R J" uniqKey="Fischer R">R.J Fischer</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Saturday, G" uniqKey="Saturday G">G Saturday</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Gilbert, S C" uniqKey="Gilbert S">S.C Gilbert</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Warimwe, G M" uniqKey="Warimwe G">G.M Warimwe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, W" uniqKey="Jia W">W Jia</name></author><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Shan, S" uniqKey="Shan S">S Shan</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Zhou, D" uniqKey="Zhou D">D Zhou</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashem, A M" uniqKey="Hashem A">A.M Hashem</name></author><author><name sortKey="Algaissi, A" uniqKey="Algaissi A">A Algaissi</name></author><author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A Agrawal</name></author><author><name sortKey="Al Amri, S S" uniqKey="Al Amri S">S.S Al-Amri</name></author><author><name sortKey="Alhabbab, R Y" uniqKey="Alhabbab R">R.Y Alhabbab</name></author><author><name sortKey="Sohrab, S S" uniqKey="Sohrab S">S.S Sohrab</name></author><author><name sortKey="Almasoud, A" uniqKey="Almasoud A">A Almasoud</name></author><author><name sortKey="Alharbi, N K" uniqKey="Alharbi N">N.K Alharbi</name></author><author><name sortKey="Peng, B H" uniqKey="Peng B">B.H Peng</name></author><author><name sortKey="Russell, M" uniqKey="Russell M">M Russell</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Tseng, C T K" uniqKey="Tseng C">C.T.K Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S.L Smits</name></author><author><name sortKey="Dekkers, D H" uniqKey="Dekkers D">D.H Dekkers</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, J A" uniqKey="Demmers J">J.A Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J Rottier</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D Osterhaus</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J Bosch</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, J C" uniqKey="Zhang J">J.C Zhang</name></author><author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name></author><author><name sortKey="Bao, J K" uniqKey="Bao J">J.K Bao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, R Y" uniqKey="Liu R">R.Y Liu</name></author><author><name sortKey="Wu, L Z" uniqKey="Wu L">L.Z Wu</name></author><author><name sortKey="Huang, B J" uniqKey="Huang B">B.J Huang</name></author><author><name sortKey="Huang, J L" uniqKey="Huang J">J.L Huang</name></author><author><name sortKey="Zhang, Y L" uniqKey="Zhang Y">Y.L Zhang</name></author><author><name sortKey="Ke, M L" uniqKey="Ke M">M.L Ke</name></author><author><name sortKey="Wang, J M" uniqKey="Wang J">J.M Wang</name></author><author><name sortKey="Tan, W P" uniqKey="Tan W">W.P Tan</name></author><author><name sortKey="Zhang, R H" uniqKey="Zhang R">R.H Zhang</name></author><author><name sortKey="Chen, H K" uniqKey="Chen H">H.K Chen</name></author><author><name sortKey="Zeng, Y X" uniqKey="Zeng Y">Y.X Zeng</name></author><author><name sortKey="Huang, W" uniqKey="Huang W">W Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="See, R H" uniqKey="See R">R.H See</name></author><author><name sortKey="Zakhartchouk, A N" uniqKey="Zakhartchouk A">A.N Zakhartchouk</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M Petric</name></author><author><name sortKey="Lawrence, D J" uniqKey="Lawrence D">D.J Lawrence</name></author><author><name sortKey="Mok, C P" uniqKey="Mok C">C.P Mok</name></author><author><name sortKey="Hogan, R J" uniqKey="Hogan R">R.J Hogan</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author><author><name sortKey="Zitzow, L A" uniqKey="Zitzow L">L.A Zitzow</name></author><author><name sortKey="Karunakaran, K P" uniqKey="Karunakaran K">K.P Karunakaran</name></author><author><name sortKey="Hitt, M M" uniqKey="Hitt M">M.M Hitt</name></author><author><name sortKey="Graham, F L" uniqKey="Graham F">F.L Graham</name></author><author><name sortKey="Prevec, L" uniqKey="Prevec L">L Prevec</name></author><author><name sortKey="Mahony, J B" uniqKey="Mahony J">J.B Mahony</name></author><author><name sortKey="Sharon, C" uniqKey="Sharon C">C Sharon</name></author><author><name sortKey="Auperin, T C" uniqKey="Auperin T">T.C Auperin</name></author><author><name sortKey="Rini, J M" uniqKey="Rini J">J.M Rini</name></author><author><name sortKey="Tingle, A J" uniqKey="Tingle A">A.J Tingle</name></author><author><name sortKey="Scheifele, D W" uniqKey="Scheifele D">D.W Scheifele</name></author><author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M Skowronski</name></author><author><name sortKey="Patrick, D M" uniqKey="Patrick D">D.M Patrick</name></author><author><name sortKey="Voss, T G" uniqKey="Voss T">T.G Voss</name></author><author><name sortKey="Babiuk, L A" uniqKey="Babiuk L">L.A Babiuk</name></author><author><name sortKey="Gauldie, J" uniqKey="Gauldie J">J Gauldie</name></author><author><name sortKey="Roper, R L" uniqKey="Roper R">R.L Roper</name></author><author><name sortKey="Brunham, R C" uniqKey="Brunham R">R.C Brunham</name></author><author><name sortKey="Finlay, B B" uniqKey="Finlay B">B.B Finlay</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Alagaili, A N" uniqKey="Alagaili A">A.N Alagaili</name></author><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author><author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V Kapoor</name></author><author><name sortKey="Sameroff, S C" uniqKey="Sameroff S">S.C Sameroff</name></author><author><name sortKey="Burbelo, P D" uniqKey="Burbelo P">P.D Burbelo</name></author><author><name sortKey="De, Wit E" uniqKey="De W">Wit E de</name></author><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J Munster</name></author><author><name sortKey="Hensley, L E" uniqKey="Hensley L">L.E Hensley</name></author><author><name sortKey="Zalmout, I S" uniqKey="Zalmout I">I.S Zalmout</name></author><author><name sortKey="Kapoor, A" uniqKey="Kapoor A">A Kapoor</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J.H Epstein</name></author><author><name sortKey="Karesh, W B" uniqKey="Karesh W">W.B Karesh</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name></author><author><name sortKey="Mohammed, O B" uniqKey="Mohammed O">O.B Mohammed</name></author><author><name sortKey="Lipkin, W I" uniqKey="Lipkin W">W.I Lipkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fahmy, N" uniqKey="Fahmy N">N Fahmy</name></author><author><name sortKey="Woo, M" uniqKey="Woo M">M Woo</name></author><author><name sortKey="Alameldin, M" uniqKey="Alameldin M">M Alameldin</name></author><author><name sortKey="Lee, J K" uniqKey="Lee J">J.K Lee</name></author><author><name sortKey="Macdonald, K" uniqKey="Macdonald K">K MacDonald</name></author><author><name sortKey="Goneau, L W" uniqKey="Goneau L">L.W Goneau</name></author><author><name sortKey="Cadieux, P" uniqKey="Cadieux P">P Cadieux</name></author><author><name sortKey="Burton, J" uniqKey="Burton J">J Burton</name></author><author><name sortKey="Pautler, S" uniqKey="Pautler S">S Pautler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bussolati, G" uniqKey="Bussolati G">G Bussolati</name></author><author><name sortKey="Gugliotta, P" uniqKey="Gugliotta P">P Gugliotta</name></author><author><name sortKey="Volante, M" uniqKey="Volante M">M Volante</name></author><author><name sortKey="Pace, M" uniqKey="Pace M">M Pace</name></author><author><name sortKey="Papotti, M" uniqKey="Papotti M">M Papotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khalifeh, M S" uniqKey="Khalifeh M">M.S Khalifeh</name></author><author><name sortKey="Stabel, J R" uniqKey="Stabel J">J.R Stabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ali, M T" uniqKey="Ali M">M.T Ali</name></author><author><name sortKey="Morshed, M M" uniqKey="Morshed M">M.M Morshed</name></author><author><name sortKey="Gazi, M A" uniqKey="Gazi M">M.A Gazi</name></author><author><name sortKey="Musa, M A" uniqKey="Musa M">M.A Musa</name></author><author><name sortKey="Kibria, M G" uniqKey="Kibria M">M.G Kibria</name></author><author><name sortKey="Uddin, M J" uniqKey="Uddin M">M.J Uddin</name></author><author><name sortKey="Khan, M A" uniqKey="Khan M">M.A Khan</name></author><author><name sortKey="Hasan, S" uniqKey="Hasan S">S Hasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, K J" uniqKey="Livak K">K.J Livak</name></author><author><name sortKey="Schmittgen, T D" uniqKey="Schmittgen T">T.D Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skelding, K A" uniqKey="Skelding K">K.A Skelding</name></author><author><name sortKey="Hickey, D K" uniqKey="Hickey D">D.K Hickey</name></author><author><name sortKey="Horvat, J C" uniqKey="Horvat J">J.C Horvat</name></author><author><name sortKey="Bao, S" uniqKey="Bao S">S Bao</name></author><author><name sortKey="Roberts, K G" uniqKey="Roberts K">K.G Roberts</name></author><author><name sortKey="Finnie, J M" uniqKey="Finnie J">J.M Finnie</name></author><author><name sortKey="Hansbro, P M" uniqKey="Hansbro P">P.M Hansbro</name></author><author><name sortKey="Beagley, K W" uniqKey="Beagley K">K.W Beagley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Arledge, K C" uniqKey="Arledge K">K.C Arledge</name></author><author><name sortKey="Chen, Y H" uniqKey="Chen Y">Y.H Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T Tseng</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, R W" uniqKey="Chan R">R.W Chan</name></author><author><name sortKey="Chan, M C" uniqKey="Chan M">M.C Chan</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Chan, L L" uniqKey="Chan L">L.L Chan</name></author><author><name sortKey="Kuok, D I" uniqKey="Kuok D">D.I Kuok</name></author><author><name sortKey="Fong, J H" uniqKey="Fong J">J.H Fong</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L Poon</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S Baric</name></author><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M Nicholls</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, I" uniqKey="Eckerle I">I Eckerle</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A Muller</name></author><author><name sortKey="Kallies, S" uniqKey="Kallies S">S Kallies</name></author><author><name sortKey="Gotthardt, D N" uniqKey="Gotthardt D">D.N Gotthardt</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambeir, A M" uniqKey="Lambeir A">A.M Lambeir</name></author><author><name sortKey="Durinx, C" uniqKey="Durinx C">C Durinx</name></author><author><name sortKey="Scharpe, S" uniqKey="Scharpe S">S Scharpe</name></author><author><name sortKey="De Meester, I" uniqKey="De Meester I">I De Meester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kidd, P" uniqKey="Kidd P">P Kidd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tatsis, N" uniqKey="Tatsis N">N Tatsis</name></author><author><name sortKey="Ertl, H C" uniqKey="Ertl H">H.C Ertl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santra, S" uniqKey="Santra S">S Santra</name></author><author><name sortKey="Seaman, M S" uniqKey="Seaman M">M.S Seaman</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Barouch, D H" uniqKey="Barouch D">D.H Barouch</name></author><author><name sortKey="Lord, C I" uniqKey="Lord C">C.I Lord</name></author><author><name sortKey="Lifton, M A" uniqKey="Lifton M">M.A Lifton</name></author><author><name sortKey="Gorgone, D A" uniqKey="Gorgone D">D.A Gorgone</name></author><author><name sortKey="Beaudry, K R" uniqKey="Beaudry K">K.R Beaudry</name></author><author><name sortKey="Svehla, K" uniqKey="Svehla K">K Svehla</name></author><author><name sortKey="Welcher, B" uniqKey="Welcher B">B Welcher</name></author><author><name sortKey="Chakrabarti, B K" uniqKey="Chakrabarti B">B.K Chakrabarti</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y Yang</name></author><author><name sortKey="Mascola, J R" uniqKey="Mascola J">J.R Mascola</name></author><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J Nabel</name></author><author><name sortKey="Letvin, N L" uniqKey="Letvin N">N.L Letvin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T Tseng</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Josset, L" uniqKey="Josset L">L Josset</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D Menachery</name></author><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E Gralinski</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Sova, P" uniqKey="Sova P">P Sova</name></author><author><name sortKey="Carter, V S" uniqKey="Carter V">V.S Carter</name></author><author><name sortKey="Yount, B L" uniqKey="Yount B">B.L Yount</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L Graham</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S Baric</name></author><author><name sortKey="Katze, M G" uniqKey="Katze M">M.G Katze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Geng, H" uniqKey="Geng H">H Geng</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K Lau</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C.C Lau</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H Chan</name></author><author><name sortKey="Li, C P" uniqKey="Li C">C.P Li</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D.Y Jin</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F Chan</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faure, E" uniqKey="Faure E">E Faure</name></author><author><name sortKey="Poissy, J" uniqKey="Poissy J">J Poissy</name></author><author><name sortKey="Goffard, A" uniqKey="Goffard A">A Goffard</name></author><author><name sortKey="Fournier, C" uniqKey="Fournier C">C Fournier</name></author><author><name sortKey="Kipnis, E" uniqKey="Kipnis E">E Kipnis</name></author><author><name sortKey="Titecat, M" uniqKey="Titecat M">M Titecat</name></author><author><name sortKey="Bortolotti, P" uniqKey="Bortolotti P">P Bortolotti</name></author><author><name sortKey="Martinez, L" uniqKey="Martinez L">L Martinez</name></author><author><name sortKey="Dubucquoi, S" uniqKey="Dubucquoi S">S Dubucquoi</name></author><author><name sortKey="Dessein, R" uniqKey="Dessein R">R Dessein</name></author><author><name sortKey="Gosset, P" uniqKey="Gosset P">P Gosset</name></author><author><name sortKey="Mathieu, D" uniqKey="Mathieu D">D Mathieu</name></author><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Jordanie</li></country></list><tree><country name="Jordanie"><noRegion><name sortKey="Ababneh, Mustafa" sort="Ababneh, Mustafa" uniqKey="Ababneh M" first="Mustafa" last="Ababneh">Mustafa Ababneh</name></noRegion><name sortKey="Alrwashdeh, Mu En" sort="Alrwashdeh, Mu En" uniqKey="Alrwashdeh M" first="Mu En" last="Alrwashdeh">Mu En Alrwashdeh</name><name sortKey="Khalifeh, Mohammad" sort="Khalifeh, Mohammad" uniqKey="Khalifeh M" first="Mohammad" last="Khalifeh">Mohammad Khalifeh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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